Papers in International Refereed Journals

Theophanous, A., Christodoulou, A., Mattheou, C., Sibai, D.S., Moss, T. and  Santama, N. (2023). Transcription factor UBF depletion in mouse cells results in downregulation of both downstream and upstream elements of the rRNA transcription network. Journal of Biological Chemistry, 299 (10):105203. doi: 10.1016/j.jbc.2023.105203.

Maimaris, G., Christodoulou, A., Santama, N. and Lederer, C.W. (2021). Regulation of ER composition and extent, and putative action in protein networks by ER/NE protein TMEM147. International Journal of Molecular Sciences, 22 (19):10231. doi: 10.3390/ijms221910231.

Christodoulou, A., Maimaris, G., Makrigiorgi, A., Charidemou, E., Lüchtenborg, C., Ververis, A., Georgiou, R., Lederer, C.W., Haffner, C., Brügger, B. and Santama, N. (2020). TMEM147 interacts with Lamin B Receptor, regulates its localization and levels, and affects cholesterol homeostasis. Journal of Cell Science, Aug 21;133(16):jcs245357. doi: 10.1242/jcs.245357.

Rankin Willsey, H., Walentek, P., Exner C.T.R., Xu Y., Lane A.B., Harland, R.M., Heald, R. and Santama, N. (2018). Katanin-like protein Katnal2 is required for ciliogenesis and brain development in Xenopus embryos. Developmental Biology, 442:276-287.

Christodoulou, A., Santarella_Melwig, R., Santama, N. and Mattaj, I.W. (2016) Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells. Journal of Cell Science, 129: 1552-1565.

Ververis, A., Christodoulou, A., Christoforou, M., Kamilari, C., Lederer, C.W. and Santama N. (2016). A novel family of katanin-like 2 protein isoforms (KATNAL2), interacting with nucleotide-binding proteins Nubp1 and Nubp2, are key regulators of different MT-based processes in mammalian cells. Cellular and Molecular Life Sciences 73: 163-184. (Cover Story).

Kypri, E., Christodoulou, A., Maimaris, G., Lethan, M., Markaki, M., Lyssandrou, C., Lederer, C.W., Tavernarakis, N., Geimer, S., Pedersen, L.B. Santama, N. (2014) The nucleotide binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis. Cellular and Molecular Life Sciences 71: 517-538.

Charalambous, D.C., Pasciuto, E., Mercaldo, V., Pilo Boyl, P., Munck, S., Bagni, C, Santama, N. (2013). KIF1Bβ transports dendritically localized mRNPs in neurons and is recruited to synapses in an activity-dependent manner. Cellular and Molecular Life Sciences 70: 335-356.

Ioannou, A., Santama, N., Skourides PA. (2013) X. laevis nucleotide binding protein 1 (xNubp1) is important for convergent extension movements and controls ciliogenesis via regulation of the actin cytoskeleton. Developmental Biology 380: 243-258.

Drakou, C.E., Malekkou, A., Hayes, J.M., Lederer, C.W., Leonidas, D.D., Oikonomakos, N.G., Lamond, A.I., Santama, N., Zographos, S.E. (2012) hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies. Proteins 80: 206-220. Epub 2011 Oct 31.

Malekkou, A., Lederer, C.W., Lamond, A.I., Santama, N. (2010) The nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition. FEBS Letters 584: 4559-4564.

Lederer, C.W. and Santama, N. (2008) Neural Stem Cells: mechanisms of fate specification and nuclear reprogramming in regenerative medicine. Biotechnology Journal 3: 1521-1538.

Lederer, C.W. and Santama, N. (2007) ALS-The tools of the trait. Biotechnology Journal 2: 608-621.

Pantelidou, M., Zographos, S.E., Lederer, C.W., Kyriakides, T., Pffafl, M.W., and Santama, N. (2007). Differential expression analysis of molecular motors in ALS motor neuron disease. Neurobiology of Disease 26: 577-589.

Lederer, C.W., Torrisi, A., Santama, N. and Cavallaro, S. (2007). Comprehensive expression profiling of motor cortex in sporadic amyotrophic lateral sclerosis. Pathways and genes differentially expressed in the motor cortex of patients with sporadic ALS. BMC Genomics 8:26 (p.1-26). Flagged as “highly accessed” by Biomed Central.

Christodoulou, A., Lederer C.W., Surrey, T., Vernos, I. and Santama, N. (2006). Motor protein KIFC5A interacts with Nubp1 and Nubp2 and is implicated in the regulation of centrosome duplication. Journal of Cell Science 119: 2035-2047.

Santama, N., Ogg S.C., Malekkou A., Zographos S.E., Weis K. and Lamond A.I. (2005). Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus. Journal of Biological Chemistry 280: 36429-36441.

Santama, N., Er, C.P., Ong, L.L. and Yu, H. (2004). Distribution and functions of kinectin isoforms. Journal of Cell Science 117: 4537-4549.

Santama, N. (2001). RT-PCR for the identification of developmentally-regulated novel members of the kinesin-like superfamily, Chapter 2, pp. 9-20. In: Neurotransmitter and Neuroreceptor Methods (I. Vernos, ed), Methods in Molecular Biology 164, Humana Press Inc. Totowa, NJ. ISBN 0-89603-766-5.

Santama, N. and Benjamin, P.R. (2000). Gene expression and function of FMRFamide-related neuropeptides in the snail Lymnaea. Special issue (K. Elekes, ed), Microscopy Research and Technique 49: 547-556.

Santama, N., Krijnse-Locker, J., Griffiths, G., Noda, Y., Hirokawa, N. and Dotti, C.G. (1998). KIF2β, a new kinesin superfamily protein, is associated with lysosomes and may be implicated in their centrifugal translocation. EMBO Journal 17: 5855-5867.

Perry, S.J., Straub,V.A., Kemenes, G., Santama, N., Worster, B.M., Burke, J.F. and Benjamin, P.R. (1998). Neural modulation of gut motility by the myomodulin peptides and acetylcholine. Journal of Neurophysiology 79: 2460-2474.

Santama, N. (1997). In situ hybridisation for the detection of neuropeptide transmitters, Chapter 12, pp. 159-170. In: Neurotransmitter and Neuroreceptor Methods (R.C. Rayne, ed), Methods in Molecular Biology 72, Humana Press Inc. Totowa, NJ. ISBN 0-89603-394-5.

Santama, N., Dotti, C.G. and Lamond, A.I. (1996b). Neuronal differentiation in the rat hippocampus involves a stage-specific re-organisation of subnuclear structure both in vivo and in vitro. European Journal of Neuroscience 8: 892-905.

Santama, N., Li, K.W., Geraerts, W.P.M., Benjamin, P.R. and Burke, J.F. (1996a). Post-translational processing of the alternative neuropeptide precursor encoded by the FMRFamide gene in the pulmonate snail Lymnaea stagnalis. European Journal of Neuroscience 8: 968-977.

Kellett, E., Perry, S.J., Santama, N., Worster, B.M., Benjamin, P.R. and Burke, J.F. (1996). Myomodulin gene of Lymnaea: structure, expression and analysis of neuropeptides. Journal of Neuroscience 16: 4949-4957.

Bohmann, K., Ferreira, J., Santama, N., Weis, K. and Lamond, A.I. (1995). Molecular analysis of the coiled body. Journal of Cell Science Suppl.19: 107-113.

Santama, N., Wheeler, C.H., Skingsley, D.R., Yeoman, M., Bright, K., Kaye, I., Burke, J.F. and Benjamin, P.R. (1995b). Identification, distribution and physiological activity of three novel peptides of Lymnaea: EFLRIamide and pQFYRIamide encoded by the FMRFamide gene, and a related peptide. European Journal of Neuroscience 7: 234-246.

Santama, N., Benjamin, P.R. and Burke, J.F. (1995a). Alternative RNA splicing generates diversity of neuropeptide expression in the brain of the snail Lymnaea: In situ analysis of mutually exclusive transcripts of the FMRFamide gene. European Journal of Neuroscience 7: 65-76.

Santama, N., Brierley, M.J., Burke, J.F. and Benjamin, P.R. (1994b). A neural network controlling feeding in Lymnaea stagnalis: Immunocytochemical localization of Myomodulin, Small Cardioactive Peptide (SCP), Buccalin and FMRFamide-related peptides. Journal of Comparative Neurology 342: 352-365.

Santama, N., Wheeler, C.H., Burke, J.F. and Benjamin, P.R. (1994a). Neuropeptides Myomodulin, Small Cardioactive Peptide (SCP) and Buccalin in the Central Nervous System of Lymnaea stagnalis: Purification, Immunoreactivity and Artifacts. Journal of Comparative Neurology 342: 335-351.

Santama, N., Li, K.V., Bright, K.E., Yeoman, M., Geraerts, W.P.M., Burke, J.F. and Benjamin, P.R. (1993). Processing of the FMRFamide precursor protein in the snail Lymnaea stagnalis: Characterisation and neuronal localization of a novel peptide, “SEEPLY”. European Journal of Neuroscience 5: 1003-1016.

Skingsley, D.R., Bright, K, Santama, N., van Minnen, J., Brierley, M.J., Burke, J.F. and Benjamin, P.R. (1993). A molecularly defined cardio-respiratory interneuron expressing SDPFLRFamide/GDPFLRFamide in the snail Lymnaea: monosynaptic connections and pharmacology. Journal of Neurophysiology 69: 915-927.

Burke, J.F., Kellett, E., De Lange, R.P.J., Santama, N., Saunders, S.E. and Benjamin, P.R. (1992). Neuropeptide FMRFamide gene expression. Methods in Neuroscience 9: 64-78. San Diego, CA, Academic Press.

Smith, A., Santama, N., Dacey, S., Edwards, M., Bray, R.C., Thorneley, R.N.F. and Burke, J.F. (1990). Expression of a synthetic gene for Horseradish Peroxidase in E. coli and folding and activation of the recombinant enzyme with Ca2+ and heme. Journal of Biological Chemistry 265: 13335-13343.

Burke, J.F., Smith, A., Santama, N., Bray, R.C., Thorneley, R.N.F., Dacey, S., Griffiths, J., Catlin, G. and Edwards, M. (1989). Expression of recombinant Horseradish Peroxidase C in E. coli. Biochemical Society Transactions 17: 1077-1078.


Chapters in Books

Textbook Human Physiology: From Cells to Systems, 8th Edition (2013) by L Sherwood, Brooks Cole, ISBN: 9781111577438,
Greek Translation, Chapter 5 (Editors: Santama, N and Sidiropoulou, K), Academic Publications J. Basdra & Co. (2016), ISBN 978-618-5135-02-7.

Textbook Human Physiology: From Cells to Systems, 8th Edition (2013) by L Sherwood, Brooks Cole, ISBN: 9781111577438,
Greek Translation, Chapter 20 (Editors: Marangos, P and Santama, N), Academic Publications J. Basdra & Co. (2016), ISBN 978-618-5135-02-7.